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<meta content="Adams, M.J." name="eprints.creators_name" />
<meta content="Oostryck, R." name="eprints.creators_name" />
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<meta content="2007-09-10" name="eprints.datestamp" />
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<meta content="A comparative study of functional assays
for tissue factor pathway inhibitor using
normal plasma and clinical samples" name="eprints.title" />
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<meta content="321008" name="eprints.subjects" />
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<meta content="tissue factor pathway inhibitor, functional assay, thrombosis" name="eprints.keywords" />
<meta content="Tissue factor pathway inhibitor (TFPI) is a Kunitz-type inhibitor that regulates the initiation of tissue factor-mediated coagulation.
Recent reports in the literature have described variable results using different methodologies for TFPI measurement. In this study,
we used one clotting and two amidolytic methodologies to assess TFPI functional levels. The study groups included normal healthy
donors as well as patients with acute hepatitis, diabetes, coronary artery bypass graft operations, deep vein thrombosis, and prior to
and during heparin therapy. The aims were to compare the results obtained in normal plasma using different assay systems, to
compare TFPI levels in a range of clinical samples, including those previously not determined using a clotting methodology, and to
report TFPI levels in patient groups previously not investigated. The results clearly demonstrate poor correlation between
functional TFPI values using the different methodologies, highlighting the requirement for standardization." name="eprints.abstract" />
<meta content="1999" name="eprints.date" />
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<meta content="Blood Coagulation and Fibrinolysis" name="eprints.publication" />
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<meta content="Adams, M.J. and Oostryck, R. (1999) A comparative study of functional assays for tissue factor pathway inhibitor using normal plasma and clinical samples. Blood Coagulation and Fibrinolysis, 11 . pp. 327-333. ISSN 0957 5235" name="eprints.citation" />
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<meta content="Oostryck, R." name="DC.creator" />
<meta content="321008 Haematology" name="DC.subject" />
<meta content="Tissue factor pathway inhibitor (TFPI) is a Kunitz-type inhibitor that regulates the initiation of tissue factor-mediated coagulation.
Recent reports in the literature have described variable results using different methodologies for TFPI measurement. In this study,
we used one clotting and two amidolytic methodologies to assess TFPI functional levels. The study groups included normal healthy
donors as well as patients with acute hepatitis, diabetes, coronary artery bypass graft operations, deep vein thrombosis, and prior to
and during heparin therapy. The aims were to compare the results obtained in normal plasma using different assay systems, to
compare TFPI levels in a range of clinical samples, including those previously not determined using a clotting methodology, and to
report TFPI levels in patient groups previously not investigated. The results clearly demonstrate poor correlation between
functional TFPI values using the different methodologies, highlighting the requirement for standardization." name="DC.description" />
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<h1 class="ep_tm_pagetitle">A comparative study of functional assays for tissue factor pathway inhibitor using normal plasma and clinical samples</h1>
<p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Adams, M.J.</span> and <span class="person_name">Oostryck, R.</span> (1999) <xhtml:em>A comparative study of functional assays for tissue factor pathway inhibitor using normal plasma and clinical samples.</xhtml:em> Blood Coagulation and Fibrinolysis, 11 . pp. 327-333. ISSN 0957 5235</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a onmouseover="EPJS_ShowPreview( event, 'doc_preview_2983' );" href="http://eprints.utas.edu.au/1813/1/Adams_Oostryck_2000.pdf" onmouseout="EPJS_HidePreview( event, 'doc_preview_2983' );"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a><div class="ep_preview" id="doc_preview_2983"><table><tr><td><img alt="" src="http://eprints.utas.edu.au/1813/thumbnails/1/preview.png" class="ep_preview_image" border="0" /><div class="ep_preview_title">Preview</div></td></tr></table></div></td><td valign="top"><a href="http://eprints.utas.edu.au/1813/1/Adams_Oostryck_2000.pdf"><span class="ep_document_citation">PDF</span></a> - Requires a PDF viewer<br />127Kb</td></tr></table><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">Tissue factor pathway inhibitor (TFPI) is a Kunitz-type inhibitor that regulates the initiation of tissue factor-mediated coagulation.
Recent reports in the literature have described variable results using different methodologies for TFPI measurement. In this study,
we used one clotting and two amidolytic methodologies to assess TFPI functional levels. The study groups included normal healthy
donors as well as patients with acute hepatitis, diabetes, coronary artery bypass graft operations, deep vein thrombosis, and prior to
and during heparin therapy. The aims were to compare the results obtained in normal plasma using different assay systems, to
compare TFPI levels in a range of clinical samples, including those previously not determined using a clotting methodology, and to
report TFPI levels in patient groups previously not investigated. The results clearly demonstrate poor correlation between
functional TFPI values using the different methodologies, highlighting the requirement for standardization.</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">tissue factor pathway inhibitor, functional assay, thrombosis</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/321008.html">320000 Medical and Health Sciences > 321000 Clinical Sciences > 321008 Haematology</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">1813</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Dr Murray J Adams</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">10 Sep 2007</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=1813;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&eprintid=1813">item control page</a></p>
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